Acetogenins from Annona muricata

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Pharmacognosy Journal

Volume

4

Issue

32

First Page

32

Last Page

37

Publication Date

11-1-2012

Abstract

Silica gel chromatography of the dichloromethane extract of the seeds of Annona muricata afforded annoreticuin-9-one (1), while the flesh of the fruit yielded cis-annoreticuin (2) and sabadelin (3). The structures of 1-3 were elucidated by extensive 1 D and 2D NMR spectroscopy and confirmed by mass spectrometry. Acetogenins 1 and 2 were first isolated from A. reticulata and A. montana, respectively. Acetogenin 1 was reported to exhibit cytotoxic activities against the human pancreatic tumor cell line (PACA-2), human prostate adenocarcinoma (PC-3) and human lung carcinoma (A-549), while 2 was reported to exhibit cytotoxicity against human hepatoma carcinoma cell line (Hep G2). © 2012 Pharmacognosy Network Worldwide [Phcog.Net].

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Digitial Object Identifier (DOI)

10.5530/pj.2012.32.7

Disciplines

Chemistry

Keywords

Annona--Analysis; Annonaceae--Analysis; Polyketides

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