A new triterpene from Barringtonia asiatica

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Natural Product Research

Volume

26

Issue

20

First Page

1869

Last Page

1875

Publication Date

10-1-2012

Abstract

The freeze-dried bark of Barringtonia asiatica afforded a new triterpene: (3,11)-11-hydroxyolean-12-en-3-yl palmitate (1). The bark also yielded mixtures of (3)-olean-12-en-3-yl palmitate (2a), (3)-urs-12-en-3-yl palmitate (2b) and (3)-olean-18-en-3-yl palmitate (2c) in a 2:1:4 ratio; -amyrin (3a), -amyrin (3b) and germanicol (3c) in a 3:1:4 ratio; 22-O-tigloylcamelliagenin A (4a) and betulinic acid (4b) in a 2:1 ratio; olean-12-en-3,16,22-triol (5), -sitosterol, spinasterol, squalene and trilinolein. The roots yielded 2a-c and 3a-c as well as trilinolein, spinasterol and squalene, while the flowers afforded verimol k (6), linoleic acid, spinasterol, squalene, phytyl fatty acid ester and trilinolein. Compounds 1-4 and 6 were tested for antimicrobial property against seven microorganisms. All compounds tested exhibited slight activity against Candida albicans and were found inactive against Escherichia coli, Bacillus subtilis, Trichophyton mentagrophytes and Aspergillus niger. Except for the mixture of 4a and 4b that proved to be inactive, all the compounds were slightly active against the bacterium Staphylococcus aureus, while 3a-c were slightly active against Pseudomonas aeruginosa.

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Digitial Object Identifier (DOI)

10.1080/14786419.2011.619187

Disciplines

Chemistry

Keywords

Lecythidaceae--Analysis

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