Date of Publication

2007

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Jaime Raul O. Janairo

Defense Panel Member

Glenn V. Alea
Alicia M. Aguinaldo

Abstract/Summary

Dichloromethane extract of the leaves of Macaranga tanarius (Linn.) Muell.-Arg. has been investigated leading to the isolation of chlorophyll a, chlorophyllide a and polyprenol. The structure of chlorophyll a and its derivative were confirmed by spectroscopic methods including NMR, IR and UV analyses while the structure of polyprenol was determined by comparison of its NMR spectral data with those reported in the literature. The chlorophyll compounds were also evaluated for their potential antimicrobial properties utilizing in vitro assays. Agar well diffusion assay results indicated that chlorophyll a exhibited low activity against P. aeruginosa and C. albicans and was found ineffective against S. aureus, B. subtilis, E. coli, T. mentagrophytes and A. niger. Its derivative- chlorophyllide a showed low activity against S. aureus, E. coli, P. aeruginosa, C. albicans and T. mentagrophytes but no inhibition in the growth of B. subtilis and A. niger were observed.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTG004295

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

ix, 169 leaves ; 28 cm.

Keywords

Porphyrins; Chlorophyll; Euphorbiaceae—Composition

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