Geoprotection by glycerol: Insights to its mechanisms and critical potentials
College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
Annals of the New York Academy of Sciences
Volume
1067
Issue
1
First Page
488
Last Page
492
Publication Date
2006
Abstract
Chaperones, particularly the heat-shock proteins, are considered as key players in the maintenance of protein homeostasis and are associated with longevity and cellular immortalization. In this study, we investigated the geroprotective activity of the chemical chaperone glycerol. Glycerol showed significant chaperoning activity in refolding heat-denatured luciferase in vivo and in protecting cells from heat stress-induced cytotoxicity. This was accompanied by decrease in p53, an upregulation of a stress chaperone mortalin/mtHsp70, and an increase in proteasome activity in the presence of oxidative stress.
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Recommended Citation
Deocaris, C. C., Shrestha, B. G., Kraft, D. C., Yamasaki, K., Rattan, S. I., & Wadhwa, R. (2006). Geoprotection by glycerol: Insights to its mechanisms and critical potentials. Annals of the New York Academy of Sciences, 1067 (1), 488-492. Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/5466
Disciplines
Molecular Biology
Keywords
Glycerin; Molecular chaperones; Aging—Prevention
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