On the brotherhood of the mitochondrial chaperons mortalin and heat stock protein 60
College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
Cell Stress and Chaperones
Volume
11
Issue
2
First Page
116
Last Page
128
Publication Date
2006
Abstract
The heat shock chaperones mortalin/mitochondrial heat shock protein 70 (mtHsp70) and Hsp60 are found in multiple subcellular sites and function in the folding and intracellular trafficking of many proteins. The chaperoning activity of these 2 proteins involves different structural and functional mechanisms. In spite of providing an excellent model for an evolutionarily conserved molecular "brotherhood", their individual functions, although overlapping, are nonredundant. As they travel to various locations, both chaperones acquire different binding partners and exert a more divergent involvement in tumorigenesis, cellular senescence, and immunology. An understanding of their functional biology may lead to novel designing and development of therapeutic strategies for cancer and aging.
html
Recommended Citation
Deocaris, C. C., Kaul, S. C., & Wadhwa, R. (2006). On the brotherhood of the mitochondrial chaperons mortalin and heat stock protein 60. Cell Stress and Chaperones, 11 (2), 116-128. Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/5297
Disciplines
Biology | Cell Biology
Keywords
Molecular chaperones; Heat shock proteins
Upload File
wf_no
