Triterpenoids and an anti-angiogenic sterol from Ardisia pyramidalis (Cav.) Pers

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Philippine Agricultural Scientist

Volume

94

Issue

2

First Page

132

Last Page

139

Publication Date

6-1-2011

Abstract

Chemical constituents of the dichloromethane extract of the leaves of Ardisia pyramidalis (Cav.) Pers were isolated and identified. Chorioallantoic membrane (CAM) vascularity assay was also conducted to determine the probable effects of these chemical constituents on the CAM of mallard duck relative to its potential anti-angiogenic properties. From the dichloromethane extract of the air-dried leaves of A. pyramidalis, we isolated spinasterol 1, spinasteryl acetate 2, a mixture of α-amyrin 3a, β-amyrin 3b and bauerenol 3c at a ratio of 2:1:2, squalene 4, lutein 5 and triglycerides 6. All were identified on the basis of nuclear magnetic resonance (NMR) spectral data. Compounds 1, 6 and the mixture of 3a, 3b and 3c demonstrated a positive vascular damage activity, whereas 1 showed possible anti-angiogenic properties characterized by capillary hemorrhaging and ghost vessels, which eventually led to a non-functional chorioallantoic membrane.

html

Disciplines

Chemistry

Keywords

Myrsinaceae--Analysis; Primulaceae--Analysis

Upload File

wf_no

This document is currently not available here.

Share

COinS