Bioactivities of triterpenes and a sterol from Syzygium samarangense

Authors

Dennis D. Raga, De La Salle University, Manila
Candice Louise C. Cheng, De La Salle University, Manila
Kate Catherine Ilona C. Lee, De La Salle University, Manila
Wileen Zoe P. Olaziman, De La Salle University, Manila
Vernon Joseph A. de Guzman, De La Salle University, Manila
Chien Chang Shen, National Research Institute of Chinese Medicine Taiwan
Francisco C. Franco Jr., De La Salle University, Manila
Consolacion Y. Ragasa, De La Salle University, Manila

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volume

66 C

Issue

5-6

First Page

235

Last Page

244

Publication Date

1-1-2011

Abstract

Cycloartenyl stearate (1a), lupenyl stearate (1b), sitosteryl stearate (1c), and 24-methylenecycloartanyl stearate (1d) (sample 1) from the air-dried leaves of Syzygium samarangense exhibited potent analgesic and anti-infl ammatory activities at effective doses of 6.25 mg/kg body weight and 12.5 mg/kg body weight, respectively. Sample 1 also exhibited negligible toxicity on zebrafi sh embryonic tissues. There were incidences of mortality upon direct exposure of sample 1 to dechorionated embryos, but higher mortality and aberration were observed during intact chorion treatment. © 2011 Verlag der Zeitschrift für Naturforschung, Tübingen.

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Digitial Object Identifier (DOI)

10.1515/znc-2011-5-606

Recommended Citation

Raga, D. D., Cheng, C. C., Lee, K. C., Olaziman, W. P., de Guzman, V. A., Shen, C., Franco, F. C., & Ragasa, C. Y. (2011). Bioactivities of triterpenes and a sterol from Syzygium samarangense. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 66 C (5-6), 235-244. https://doi.org/10.1515/znc-2011-5-606

Disciplines

Chemistry

Keywords

Syzygium; Logperch—Toxicity testing; Analgesics; Anti-inflammatory agents

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