"Triterpenes from Ardisia squamulosa C. Presl (Myrsinaceae) limit angio" by Dennis D. Raga, Annabelle A. Herrera et al.
 

Triterpenes from Ardisia squamulosa C. Presl (Myrsinaceae) limit angiogenesis and the expression of von Willebrand factor in duck chorioallantoic membrane

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Journal of Chemical and Pharmaceutical Research

Volume

5

Issue

10

First Page

230

Last Page

239

Publication Date

11-25-2013

Abstract

A mixture of bauerenol (1a), a-amyrin (1b) and b-amyrin (1c) in a 3:1:2 ratioobtained from the dichloromethane extract of air-dried leaves of Ardisia squamulosa was tested on duck chorioallantoic membrane (CAM). The mixture of 1a-1c exhibited inhibition of vascularization and formation of ghost vessels on CAMswith 100% embryo survivability at the end of a 9-day treatment period. A possible angio-suppression by inhibition of branch point formation, reduction of inter-capillary distance as well as reduced vascular density in CAMs administered with 1a- 1care also reported. Immunohistochemistry reveals high degree of von Willebrand factor expression and the absence of epithelial membrane antigen. This suggests that the observed angio-suppression was due to the effect of von Willebrand factor in regulation of other angiogenesis modulators.

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Disciplines

Chemistry

Keywords

Myrsinaceae--Analysis; Von Willebrand factor

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