Angio-suppressive triterpenoids from Ardisia cf. elliptica (subgenus Tinus) on duck (Anas platyrynchosL.) chorioallantoic membrane

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Chinese Journal of Natural Medicines

Volume

11

Issue

2

First Page

128

Last Page

138

Publication Date

1-1-2013

Abstract

The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes (1a-1c) at ratios of 2:2:1, 2:2:3 and 1:1:1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM). All three ratios were found to be effective in restricting inter-capillary length, while 1a-1c (2:2:1) was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of 1a-1c (2:2:1). © 2013 China Pharmaceutical University.

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Digitial Object Identifier (DOI)

10.1016/S1875-5364(13)60039-4

Disciplines

Chemistry

Keywords

Primulaceae--Analysis

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