Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture

College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

Journal of Parasitology

Volume

89

Issue

3

First Page

604

Last Page

606

Publication Date

1-1-2003

Abstract

The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi and B. caballi. Clotrimazole (IC50: 2 and 17 μM), KC (IC50: 6 and 22 μM), and CP (IC50: 450 and 354 μM) were effective growth inhibitors. Interestingly, intraerythrocytic KC-treated Babesia sp. were observed to be in immediate contact with the plasma fraction of the blood in electron microscopy. These results demonstrate the babesiacidial activities of these compounds and suggest their chemotherapeutic potential for the treatment of equine babesioses.

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Digitial Object Identifier (DOI)

10.1645/0022-3395(2003)089[0604:CKACAP]2.0.CO;2

Disciplines

Biology

Keywords

Babesia; Babesiosis; Antifungal agents

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