Clotrimazole, ketoconazole, and clodinafop-propargyl inhibit the in vitro growth of babesia bigemina and babesia bovis (Phylum Apicomplexa)
College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
Parasitology
Volume
127
Issue
4
First Page
311
Last Page
315
Publication Date
10-1-2003
Abstract
We evaluated the growth inhibitory efficacy of the imidazole derivatives, clotrimazole (CLT) and ketoconazole (KC), and the herbicide clodinafop- propargyl (CP), in in vitro cultures of Babesia bovis and B. bigemina. Clotrimazole was effective in a dose range of 15 to 60 μM (IC 50:11 and 23.5 μM), followed by KC (50 to 100 μM; IC 50 : 50 and 32 μM) and CP (500 μM; IC50 : 265 and 390 μM). In transmission electron microscopy, extensive damage was observed in the cytoplasm of drug-treated parasites. Combinations of CLT/KC, CLT/CP and CLT/KC/CP acted synergistically in both parasites. In contrast, the combination of KC/CP was exclusively effective in B. bovis, but not in B. bigemina.
html
Digitial Object Identifier (DOI)
10.1017/S0031182003003895
Recommended Citation
Bork, S., Yokoyama, N., Matsuo, T., Claveria, F. G., Fujisaki, K., & Igarashi, I. (2003). Clotrimazole, ketoconazole, and clodinafop-propargyl inhibit the in vitro growth of babesia bigemina and babesia bovis (Phylum Apicomplexa). Parasitology, 127 (4), 311-315. https://doi.org/10.1017/S0031182003003895
Disciplines
Biology
Keywords
Babesiosis in cattle; Babesia bigemina; Ketoconazole; Antifungal agents
Upload File
wf_yes