Angio-suppressive effect of sterols from Ardisia Pyramidalis (Cav.) Pers
College
College of Science
Department/Unit
Chemistry
Document Type
Article
Source Title
Pharmaceutical Chemistry Journal
Volume
51
Issue
8
First Page
683
Last Page
689
Publication Date
11-1-2017
Abstract
Spinasterol (1) and spinasteryl acetate (2) from the leaves of Ardisia pyramidalis (Cav.) Pers. (Myrsinaceae) were tested on duck chorioallantoic membrane (CAM) vascularity assay. The petechial to severe hemorrhaging, hyperemia, and the formation of ghost vessels were observed in CAMs treated with compounds 1 and 2. Both sterols have effectively suppressed blood vessel branching and inter-capillary elongation. High degree of vonWillebrand factor expression was observed in these CAMs treated with 1 and 2. This is further confirmed by the absence of the epithelial membrane antigen in all samples tested, suggesting that the main mechanism of angio-suppression is related to the action of von Willebrand factor which modulates other angiogenic factors. Spinasterol was found to be most effective in reducing the branch point formation and inter capillary distance with very minimal incidence of mortality, thus suggesting its potential as a source of phytopharmaceuticals. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.
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Digitial Object Identifier (DOI)
10.1007/s11094-017-1674-4
Recommended Citation
Raga, D. D., Herrera, A. A., Alimboyoguen, A. B., Shen, C., & Ragasa, C. Y. (2017). Angio-suppressive effect of sterols from Ardisia Pyramidalis (Cav.) Pers. Pharmaceutical Chemistry Journal, 51 (8), 683-689. https://doi.org/10.1007/s11094-017-1674-4
Disciplines
Chemistry
Keywords
Primulaceae--Analysis; Blood-vessels—Growth; Chorioallantois
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