Hypoglycemic effects of tea extracts and sterols from Momordica charantia

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Journal of Natural Remedies

Volume

11

Issue

1

First Page

44

Last Page

53

Publication Date

1-1-2011

Abstract

Mice administered with different doses of infusion obtained from commercial tea preparations of Momordica charantia fruit and leaf displayed variable hypoglycemic activity. M. charantia fruit tea extract at 100 mg/kg BW had demonstrated significant (P=0.001) blood glucose lowering during 0.5h to 1.0h observation period, while M. charantia leaf tea extract was most effective at 100 mg/kg BW with sustained blood glucose reduction pattern starting at 1.5h to 2.5h. The dichloromethane extract of the freeze-dried fruit of M. charantia afforded a mixture of clerosterol (1a) and 5a-stigmasta-7-en-3B-ol (1b) in a 2:1 ratio by silica gel chromatography. A single intraperitonial injection of 10 mg/kg BW of a mixture of 1a and 1b in normoglycemic mice significantly (P < 0.05) reduced the blood glucose level with distinct percent blood glucose reduction from 1.5h to 2.0h compared with the negative control.

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Disciplines

Chemistry

Keywords

Hypoglycemic agents; Tea; Momordica charantia

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