Date of Publication

2022

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology major in Medical Biology

Subject Categories

Biology

College

College of Science

Department/Unit

Biology

Thesis Advisor

Jose Isagani B. Janairo

Defense Panel Chair

Maria Carmen A. Lagman

Defense Panel Member

Chona Camille Vince Cruz - Abeledo
Eligio Santiago V. Maghirang

Abstract/Summary

Colitis is an immunologically mediated disease characterized by inflammation in the gut and currently affects over 6 million individuals worldwide. Silver nanoparticles have been introduced as a novel therapy for colitis due to its anti-inflammatory properties. However, current studies have yielded conflicting results regarding silver nanoparticles on colonic recovery. In line with this, this study aims to perform a meta-analysis to deliver a comprehensive conclusion on the efficacy of silver nanoparticles as treatment for colitis.
A systematic literature search was conducted using databases, such as PubMed, Scopus, Google Scholar, and ScienceDirect. Data from eligible articles were analyzed using Review Manager 5.4.1 for generation of forest plots reporting the outcome measures of colon length, colon weight, myeloperoxidase (MPO) activity, disease activity index (DAI) score, and microscopic score. The mean differences were calculated and interpreted. Subgroup analysis was conducted for forest plots yielding high heterogeneity.
A total of 5 journal articles were included. Results of the study showed that silver nanoparticles held significant therapeutic effect for all outcome measures, especially for colonic length which was the primary outcome of interest. It was found that the anti-inflammatory effects of silver nanoparticles were dependent on nanoparticle morphology and dosage. Results also showed that combination therapy of silver nanoparticles with known anti-inflammatory drugs, such as sulfasalazine and mesalamine, yielded greater therapeutic effects on the mouse models.
This meta-analysis found that silver nanoparticles exhibit a significant therapeutic effect on colitis-induced mouse models. It is recommended that future studies proceed to clinical trials to evaluate the effect of silver nanoparticles on a human model.

Abstract Format

html

Language

English

Format

Electronic

Physical Description

x, 115 leaves

Keywords

Colitis; Nanoparticles; Silver--Therapeutic use

Upload Full Text

wf_yes

Embargo Period

8-24-2023

Download

Share

COinS