Date of Publication

11-19-2025

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology major in Medical Biology

Subject Categories

Biology | Molecular Biology

College

College of Science

Department/Unit

Biology

Thesis Advisor

Marigold O. Uba

Defense Panel Chair

John Paul S. Domingo

Defense Panel Member

Gliceria B. Ramos
Patricio Elvin L. Cantiller

Abstract (English)

Liver cancer is the second leading cause of cancer-related deaths in the Philippines. Despite advancements in diagnostic tools, it is often detected only at advanced stages, resulting in poor prognosis and limited treatment options. Emerging studies highlight the oral–gut–liver axis, suggesting that gastrointestinal diseases, including liver cancer, may manifest through dysbiosis in the oral microbiota. The genus Porphyromonas has been found to exhibit a significant increase in abundance within the oral microbial profiles of liver cancer patients, indicating its potential as a non-invasive biomarker for early detection. This systematic review synthesizes evidence on the presence and relative abundance of Porphyromonas spp. in liver cancer patients, and evaluates their diagnostic performance in terms of sensitivity, specificity, and predictive value. Relevant studies were retrieved from PubMed, ScienceDirect, and Scopus, obtaining a total of nine (9) research articles for assessment from an initial record of 2,424 studies. Studies consistently showed that Porphyromonas spp. were more abundant in liver cancer patients than in healthy or liver disease groups, and the invasive P. gingivalis fimA II genotype appeared more frequently in liver cancer than in liver disease. The current known pathways through which Porphyromonas spp. influences liver pathology include endothelial permeability, lipid accumulation, insulin signaling, and ferroptosis. These papers provide evidence on the role of Porphyromonas spp. in the liver, from its quantitative presence to its invasive and immunological implications that support the emergence of new biomarkers for the detection of liver cancer.

Abstract Format

html

Abstract (Filipino)

Ang liver cancer ay ang pangalawang pinakapangunahing sanhi ng pagkamatay na nauugnay sa kanser sa Pilipinas. Sa kabila ng pagsulong ng mga diagnostic tools, madalas itong natutuklasan lamang kapag ito ay malubha na, na nagiging sanhi ng hindi magandang prognosis at limitadong treatment options. Ang mga bagong pag-aaral tungkol sa oral–gut–liver axis ay nagsasabing ang mga sakit sa gastrointestinal, kabilang ang liver cancer, ay maaaring makita sa pamamagitan ng dysbiosis sa oral microbiota. Ang genus na Porphyromonas ay natuklasang may makabuluhang pagtaas ng dami sa oral microbiome profiles ng mga pasyenteng may liver cancer, na nagpapahiwatig ng potensyal nito bilang isang non-invasive biomarker para sa maagang deteksyon. Ang systematic review na ito ay nagbubuod ng mga ebidensya tungkol sa presensya at relative abundance ng Porphyromonas spp. sa mga pasyenteng may liver cancer, at sinusuri ang kanilang diagnostic performance sa sensitivity, specificity, at predictive value. Ang mga kaugnay na pag-aaral na nakuha mula sa PubMed, ScienceDirect, and Scopus, ay mayroong kabuuan na siyam (9) na research articles para sa pagsusuri mula sa inisyal na 2,424 na pag-aaral. Pare-parehong nagpapakita ang mga pag-aaral na ang Porphyromonas spp. ay mas marami sa mga pasyenteng may liver cancer kaysa sa mga pasyenteng malusog o may liver disease, at ang invasive P. gingivalis fimA II genotype ay mas madalas matagpuan sa liver cancer kaysa sa liver disease. Ang mga kasalukuyang kilalang pathways kung saan nakakaapekto ang Porphyromonas spp. sa liver pathology ay kinabibilangan ng endothelial permeability, lipid accumulation, insulin signaling, at ferroptosis. Ang mga pag-aaral na ito at nagbibigay ng ebidensya sa papel ng Porphyromonas spp. sa atay, mula quantitative presence nito hanggang sa invasive at immunological implications na sumusuporta sa paglitaw ng bagong biomarkers para sa deteksyon ng liver cancer.

Abstract Format

html

Language

English

Format

Electronic

Keywords

Porphyromonas; Liver—Cancer; Biochemical markers

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Embargo Period

12-10-2025

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