Isolation and structural elucidation of secondary metabolites from Sesbania grandiflora (Linn.) pers and Heliotropium indicum Linn

Date of Publication

2004

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Jaime Raul O. Janairo

Defense Panel Member

Glenn V. Alea
Alicia Aguinaldo

Abstract/Summary

The air-dried flowers of Sesbania grandiflora (Linn.) Pers. (katuray) afforded a roughly 3:2 mixture of stigmasterol (SG3a, major compound) and sitosterol (SG3b, minor compound), and oleanolic acid (SG19), while the air-dried leaves of Heliotropium indicum Linn. (higad-higaran) yielded β-carotene (J1), lutein (J2), a mixture of polyprenols (J3), and another mixture of sitosterol (J4a, major compound) and stigmasterol (J4b, minor compound). The structures of SG3a, SG3b, and J1 were elucidated by extensive 1D and 2D NMR analyses, and the rest of the isolates were compared with their respective 1H-NMR data found in the literature This is the first report on the full structure elucidation of SG3a, SG3b and J1 by NMR spectroscopy. Antimicrobial activity tests on J1 indicated that it has high activity against Pseudomonas aeruginosa and Aspergillus niger, slight activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Trichophyton mentagrophytes, and inactive against Bacillus subtilis.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTG003642

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

1 computer optical disc ; 4 3/4 in.

Keywords

Legumes; Sesbania; Metabolites; Biological products; Heliotropium

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