1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
Date of Publication
1985
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry
Subject Categories
Chemistry | Education
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Luzvisminda U. Rivero
Defense Panel Chair
Fred Dewey
Defense Panel Member
Luz Paca
Cecile Bayquen
Abstract/Summary
The 3' / 5'-OH and the 2'-OH/amino/imino functions of adenosine, cytidine and uridine were protected with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TIPDSiCl2) and 2,2,2-trichloro-tertiarybutylesterchloroformate (TCBOC-C1), respectively in two stages. Cleavage of the tetraisopropyldisiloxyl group was attempted using hydronium and flouride ions. NMR analysis showed partial deblocking at the 5'-position.
Abstract Format
html
Language
English
Format
Accession Number
TG01363
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
78 leaves; 28 cm.
Keywords
Ribonucleosides
Recommended Citation
Arnaez, M. V. (1985). 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides. Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/1121
