New chromomoric acid derivatives from Tectona philippinensis and other secondary metabolites from Philippine medicinal plants

Date of Publication

11-7-2007

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Chemistry

Subject Categories

Biochemistry | Chemicals and Drugs

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Jaime Raul O. Janairo

Defense Panel Member

Glenn V. Alea
Marissa G. Noel
Eric R. Punzalan
Alicia M. Aguinaldo

Abstract/Summary

A total of twelve compounds were isolated from the six Philippine medicinal plants covered in this study. The DCM extract of the air-dried leaves of Tectona philippinensis afforded three new chromomoric acid derivatives (Te7, Te5, and Te6). Their structures were elucidated by extensive 1D and 2D NMR spectroscopy and MS. Te7 Te5 Te6 The air-dried leaves of Pycnarrhena manillensis afforded two known compounds namely; stigmast-4-en-3,6-dione (NT1) and stigmast-4-en-3-one (NT9). Their structures were elucidated by 1D and 2D NMR spectroscopy. Two known compounds, 2,2’:5’,2’’-terthiophene (MG1) and 5,7,4’- trihyfroxyflavone (MG24b) were isolated from the DCM extract of the air-dried flowers of Tagetes erecta. The structure of MG1 was elucidated by 1D and 2D NMR spectroscopy while MG24b was identified by comparison of its 1 H and 13C NMR spectral data with those found in the literature The flavonone, Eriodictyol (Hb20) was obtained from the air-dried flowers of Helichrysum bracteatum. The structure of Hb20 was confirmed by comparison of its 1 H and 13C NMR spectral data with those in the literature. A sesquiterpene germacranolide, 11,13-dehydrolanuginolide (CH1) was isolated from the DCM extract of the air-dried flowers of Michelia champaca. CH1 was elucidated by 1D and 2D NMR spectroscopy. The air-dried flowers of Tithonia diversifolia afforded three known compounds; Tagitinin C (HA19), faradiol ester (HA15), and squalene (HA1). Tagitinin C was elucidated by 1D and 2D NMR spectroscopy. Ha15 and HA1 were identified by comparison of their 1 H and 13C NMR spectral data with those in the literature. The anti-microbial tests on HA19 indicated slight to moderate anti-microbial properties on the microorganisms employed.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTG004791

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

xix, 433 leaves, 28 cm.

Keywords

Tectona—Analysis; Metabolites; Medicinal plants—Philippines

Upload Full Text

wf_yes

Embargo Period

5-29-2022

This document is currently not available here.

Share

COinS