Effect of 2.2-dimethoxypropane in the synthesis of 1.2 : 5.6-DI-O-Isopropylidene-o-D-Glucofuranose under different reaction condition
Date of Publication
1992
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Chemistry
Subject Categories
Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Gerardo C. Janairo
Abstract/Summary
Three separate samples of glucose are each dissolved in acetone after which zinc(II) chloride and phosphoric acid are added. Another three separate samples of glucose are also prepared as described above except for the addition of 2.2-dimethoxypropane on each. These two sets of samples are carried out in three separate condition under sonication, heating and stirring. The progress of the reaction is monitored for every hour using TLC.
The rate of reaction is comparable for both sonication and heating but slower for the stirring condition. The reaction is completed between the 9th and 23rd hour. The addition of 2.2-dimethoxypropane has no effect on the rate of reaction. Each of the solution is neutralized and filtered through suction and are then concentrated using rotary evaporator. The crude products are extracted several times with dichloromethane.
Column chromatography is employed to isolate and purify the products. A higher percentage yield is obtained in the samples with 2.2-dimethoxypropane. The compounds are then characterized by melting point, infrared absorption spectroscopy and nuclear magnetic resonance spectroscopy.
Abstract Format
html
Language
English
Format
Accession Number
TU17444
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
29, [4] leaves : illustrations ; 28 cm.
Keywords
Glucose; Chemical tests and reagents
Recommended Citation
Nery, M., & Sy, J. O. (1992). Effect of 2.2-dimethoxypropane in the synthesis of 1.2 : 5.6-DI-O-Isopropylidene-o-D-Glucofuranose under different reaction condition. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/7854
