Synthesis of an anacardic acid derivative of Thiazolidinedione

Date of Publication

2016

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Glenn V. Alea

Defense Panel Member

Faith Marie G. Lagua
Jaime Raul O. Janairo

Abstract/Summary

An anacardic acid derivative of Thiazolidinedione was synthesized. The preparation of the target compound which may have potential activity against Mycobacterium tuberculosis and cancer cells involved the extraction of anacardic acid from cashew nutshell by base precipitation. The olefinic part of the isolated anacardic acid was cleaved and converted to an aldehyde precursor via performic acid epoxidation. The resulting 2-Hydroxy-6-(8-oxooctyl)benzoic acid was coupled with thiazolidine-2,4-dione via Knoevenagel Condensation. The characterizations of the precursor and target compounds were carried out using the ESI-MS and FTIR. Reactions were monitored via thin layer chromatography. The obtained results showed that the compound was successfully synthesized. However, the characterization made was incomplete. Further characterization via 1H and !3c nuclear magnetic resonance (NMR) and mass spectrometry (MS) and the testing for activity against cancer cells and Mycobacterium tuberculosis are recommended.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU21494

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

79 leaves, illustrations (some color), 28 cm.

Keywords

Lipids—Synthesis

Embargo Period

5-4-2021

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