Effects of glutaphos and L-glutamine on the histology of hepatics steatosis in mice (Mus musculus) fed with a high fat formulation

Date of Publication

2009

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

Subject Categories

Animal Sciences | Animal Studies | Biology

College

College of Science

Department/Unit

Biology

Abstract/Summary

Two commercial dietary supplements, Glutaphos (a brain supplement) and LGlutamine (a muscle enhancer), were administered to mice (Mus muculus) together with forced-feeding of a lard and corn oil formulation. Thirty-six four month-old male mice were divided into 4 groups, namely Group I (negative control), Group II (positive control), Group III (Glutaphos) and Group IV (L-glutamine). Gross liver histology and individual hepatocytes were examined. The lard and corn oil formulation induced fatty liver in all the mice of Group II. Glutaphos-treated mice had significantly lower incidence and severity of fatty liver than the positive control. Similarly, L-glutaminetreated mice had significantly lower incidence and severity of fatty liver than the positive control. L-glutamine was significantly more effective at reducing the incidence and severity of fatty liver than Glutaphos. The proposed physiological mechanism for this effect is the ability of both Glutaphos and L-glutamine to reduce the plasma insulin:glucagon ratio which reduced lipogenesis in the liver.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTU019090

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

1 computer disc ; 4 3/4 in.

Keywords

Mice—Histology; Dietary supplements—Physiological aspects

Embargo Period

4-18-2021

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