Effects of glutaphos and L-glutamine on the histology of hepatics steatosis in mice (Mus musculus) fed with a high fat formulation
Date of Publication
2009
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Biology
Subject Categories
Animal Sciences | Animal Studies | Biology
College
College of Science
Department/Unit
Biology
Abstract/Summary
Two commercial dietary supplements, Glutaphos (a brain supplement) and LGlutamine (a muscle enhancer), were administered to mice (Mus muculus) together with forced-feeding of a lard and corn oil formulation. Thirty-six four month-old male mice were divided into 4 groups, namely Group I (negative control), Group II (positive control), Group III (Glutaphos) and Group IV (L-glutamine). Gross liver histology and individual hepatocytes were examined. The lard and corn oil formulation induced fatty liver in all the mice of Group II. Glutaphos-treated mice had significantly lower incidence and severity of fatty liver than the positive control. Similarly, L-glutaminetreated mice had significantly lower incidence and severity of fatty liver than the positive control. L-glutamine was significantly more effective at reducing the incidence and severity of fatty liver than Glutaphos. The proposed physiological mechanism for this effect is the ability of both Glutaphos and L-glutamine to reduce the plasma insulin:glucagon ratio which reduced lipogenesis in the liver.
Abstract Format
html
Language
English
Format
Electronic
Accession Number
CDTU019090
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
1 computer disc ; 4 3/4 in.
Keywords
Mice—Histology; Dietary supplements—Physiological aspects
Recommended Citation
Co, C. C., & Lujero, L. D. (2009). Effects of glutaphos and L-glutamine on the histology of hepatics steatosis in mice (Mus musculus) fed with a high fat formulation. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/5284
Embargo Period
4-18-2021