The effect of EDTA on gamma-irradiated female albino mice (Mus musculus)

Date of Publication

1994

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

College

College of Science

Department/Unit

Biology

Abstract/Summary

Four groups of 3 female albino mice each were subjected to the following treatments: control group, treatment 1 with EDTA and without gamma rays, treatment 2 without EDTA and with gamma rays and treatment 3 with both EDTA and gamma rays. Two trials were performed for each treatment. EDTA was injected intraperitoneally 25 minutes prior to exposure to 550 rads of gamma radiation. The RBC, WBC and platelet counts and body and spleen weights of the mice were measured. The parameters were counted on the 2nd, 5th and 11th day after the administration of EDTA and gamma radiation. Gamma radiation induced biological damage as manifested in the low blood counts, spleen weights and body weights. EDTA, as a radioprotector, did not prevent the destruction of the elements of the circulating blood and organs but lessened the extent of biological damage and helped in their recovery. However, EDTA, being a toxic substance, produced its own harmful effects in the circulating blood and spleen weight.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU06387

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

130 leaves

Keywords

Mice; Effect of radiation on; Ethylenediaminetetraacetic acid; Blood--Analysis and chemistry; EDTA

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