The effect of Acetaminophen on Mesocricetus auratus (golden hamster) organs

Date of Publication

1999

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

Subject Categories

Biology

College

College of Science

Department/Unit

Biology

Abstract/Summary

Thirty Mesocricetus auratus (Golden Hamster) were treated with pure acetaminophen diluted in distilled water at 100, 200, 400 and 800-mg,kg bodyweight every other day for a duration of two months. Results showed that there was cellular swelling, sinusoidal congestion, and necrosis in the liver cells specifically the group that received the highest among of acetaminophen. The kidney showed minimal damage while no damage was noted in the small intestine in all dosages. This was due to the fact that acetaminophen is mainly hapatotoxic and is utilized in the liver therefore there was no damage on the kidney tubules and intestinal mucosa. This drug is dose dependent wherein toxicity to the body increases, more the drug is used-chronically thus it should be taken in moderation.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU08976

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

39 leaves ; Computer print-out.

Keywords

Acetaminophen; Golden hamster--Spermatozoa. Golden hamster--Development; Spermatogenesis in animals

Embargo Period

12-16-2021

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