A Systematic Review on the Efficacy of Common Antacid Components

Proponent/s Name/s (Last Name, First Name, Middle Initial)

Ma. Fatima Jesuniña M. Gornez, De La Salle University Integrated School, Biñan City, Laguna
Hailey Vanessa G. Mendoza, De La Salle University Integrated School, Biñan City, Laguna
Timothy P. Rapacon, De La Salle University Integrated School, Biñan City, Laguna
Errol Joriz N. Solano, De La Salle University Integrated School, Biñan City, Laguna

Document Types

Paper Presentation

School Code

N/A

School Name

De La Salle University Integrated School, Biñan City, Laguna

Abstract/Executive Summary

Gastroesophageal Reflux Disease (GERD) is a common health issue worldwide that utilizes antacids to mitigate its symptoms such as chest pains and burning sensations. However, the most common component used in antacids, Aluminum Hydroxide, has a high toxicity level as it builds up in the body. Thus, this study aims to determine whether Alginate, an organic compound, and Calcium Carbonate, which is considered an age-friendly component, are suitable antacid component alternatives to Aluminum Hydroxide in terms of their corresponding Acid Neutralization Capacity (ANC) and adverse effects. The researchers utilized a systematic review approach, guided by the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P), to accomplish the study objectives. The study results suggest that Calcium Carbonate has the highest ANC while Alginate has the second-highest ANC and has fewer adverse effects than placebo. These results support the claim that Alginate and Calcium Carbonate are suitable alternatives to Aluminum Hydroxide.

Keywords

antacid; gastroesophageal reflux disease; calcium carbonate; alginate; systematic review

Research Theme (for Paper Presentation and Poster Presentation submissions only)

Food, Nutrition, and Health (FNH)

Initial Consent for Publication

yes