Exploring the DNA intercalating potential of glycosylated tetrathiafulvene (TTF) and dithiolene derivatives
College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
Analele Universitatii Bucuresti Chimie
Volume
20
Issue
1
First Page
25
Last Page
30
Publication Date
12-1-2011
Abstract
The DNA intercalating potential of the previously prepared water-soluble glycosylated tetrathiafulvene (TTF) and dithiolene derivatives was assessed through comparative docking analysis using doxorubicin as the reference molecule. Comparing the binding orientations and statistical evaluation of the ten lowest energy poses of each molecule with doxorubicin revealed that the glycosylated TTF derivatives are more likely to possess DNA intercalating activity since they posses lower energy values although adopted a different binding orientation. Results obtained will provide important preliminary insight on the possible biological applications of these glycoconjugates and may aid further development of these compounds for the intention of utilizing them as anti-tumor agents. © 2011 Analele Universitǎţii din Bucuresti.
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Recommended Citation
Janairo, J. B., & Janairo, G. C. (2011). Exploring the DNA intercalating potential of glycosylated tetrathiafulvene (TTF) and dithiolene derivatives. Analele Universitatii Bucuresti Chimie, 20 (1), 25-30. Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/956
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