Synthesis of two novel isonicotinoylhydrazones

Authors

Glenn V. Alea, De La Salle University, Manila
Paolo Miguel G. Aguirre, De La Salle University, Manila
Kaye Eunice L. Lustestica, De La Salle University, Manila
Michael Dominic M. Ajero, De La Salle University, Manila
Faith Marie G. Lagua, De La Salle University, Manila

College

College of Science

Department/Unit

Chemistry

Document Type

Conference Proceeding

Source Title

15th Osaka University - De La Salle University Joint Academic Research Symposium

Publication Date

2010

Abstract

Isonicotinoylhydrazone derivatives of methy 5-acetylsalicylate (2) and methyl 5-octanoylasalicylate (4) were synthesized and characterized. The synthesis involves the Friedel-Crafts acylation of methyl salicylate with acetyl chloride and octanoyl chloride using ZnCl₂ as catalyst to generate the methyl 5-acetylsalicylate (1) and methyl 5-octanoylasalicylate (3) precursor compounds. These compounds were then attached to isoniazid via imine formation to produce the corresponding Isonicotinoylhydrazone derivatives (2) and (4), which were obtained as yellow crystals in 24.16% and in 35.60% yields respectively. Compound (2) has shown to have anti-fungal properties against Calbicans, T.mentagrophytes, and A.niger.

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Recommended Citation

Alea, G. V., Aguirre, P. G., Lustestica, K. L., Ajero, M. M., & Lagua, F. G. (2010). Synthesis of two novel isonicotinoylhydrazones. 15th Osaka University - De La Salle University Joint Academic Research Symposium Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/7782

Disciplines

Chemistry

Keywords

Isoniazid—Synthesis; Mycobacterium tuberculosis

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