Stochastic process algebra modeling of APP processing influenced by SORLA in Alzheimer's disease

College

College of Science

Department/Unit

Mathematics and Statistics Department

Document Type

Conference Proceeding

Source Title

2014 Mathematical Society of the Philippines Annual Convention

Publication Date

2014

Abstract

Alzheimer's disease (AD) is a fatal neurodegenerative disorder caused by the formation of neurotoxic beta-amyloid (Aβ) peptides, resulting from the proteolytic breakdown of amyloid precursor protein (APP) by secretases. In this study, I use stochastic process algebra (SPA), a more straightforward approach in modelling system with compartmental components, to model the processing of APP influenced by SORLA, a neuraI sorting receptor. I have shown that the expressivity of the SPA­-based model at the biochemical level is comparable to the ODE-based compartmental model that I developed earlier for APP processing. However, to determine if SPA can be used as an alternative to compartmental modeling, I have to evaluate the behaviour and predictive power of SPA using SPiM and MATLAB.

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Disciplines

Other Mathematics

Keywords

Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease

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