"Stochastic process algebra modeling of APP processing influenced by S" by Angelyn R. Lao
 

Stochastic process algebra modeling of APP processing influenced by SORLA in Alzheimer's disease

College

College of Science

Department/Unit

Mathematics and Statistics Department

Document Type

Conference Proceeding

Source Title

2014 Mathematical Society of the Philippines Annual Convention

Publication Date

2014

Abstract

Alzheimer's disease (AD) is a fatal neurodegenerative disorder caused by the formation of neurotoxic beta-amyloid (Aβ) peptides, resulting from the proteolytic breakdown of amyloid precursor protein (APP) by secretases. In this study, I use stochastic process algebra (SPA), a more straightforward approach in modelling system with compartmental components, to model the processing of APP influenced by SORLA, a neuraI sorting receptor. I have shown that the expressivity of the SPA­-based model at the biochemical level is comparable to the ODE-based compartmental model that I developed earlier for APP processing. However, to determine if SPA can be used as an alternative to compartmental modeling, I have to evaluate the behaviour and predictive power of SPA using SPiM and MATLAB.

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Disciplines

Other Mathematics

Keywords

Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease

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