Molecular importance of new roles of retinoids in biological systems: A review

College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

CvSU Research Journal

Volume

13

Issue

1&2

First Page

74

Last Page

86

Publication Date

1999

Abstract

Retinoids, a group of compounds which include Vitamin A, has recently been shown to play new roles in gene regulation specifically controlling expression of homeotic genes. The implication of this role to developmental process particularly axial patterning, teratogenesis and cancer treatment is discussed. Mechanism for retinoid's molecular action is presented. The occurrence of DNA-binding retinoid receptors (RAR and RXRs) and the identification of several retinoic acid response elements (RAREs) evidenced retinoid' s molecular importance to cell. Updated review on absorption, metabolism, function, deficiency effects and retinoid binding proteins is included.

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Disciplines

Biochemistry, Biophysics, and Structural Biology

Keywords

Retinoids

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