Extract from Acanthopanax senticus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain

College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

Bioscience, Biotechnology, and Biochemistry

Volume

72

Issue

9

First Page

2476

Last Page

2480

Publication Date

9-2008

Abstract

The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.

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Disciplines

Biology

Keywords

Acanthopanax senticosus; Brain stimulation; Hypothalamus; Medulla oblongata

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