Neural analyses validate and emphasize the role of progesterone receptor in breast cancer progression and prognosis

College

College of Computer Studies

Department/Unit

Information Technology

Document Type

Article

Source Title

Anticancer Research

Volume

36

Issue

4

First Page

1909

Last Page

1915

Publication Date

4-1-2016

Abstract

Oestrogen receptor (ER) expression is routinely measured in breast cancer management, but the clinical merits of measuring progesterone receptor (PR) expression have remained controversial. Hence the major objective of this study was to assess the potential of PR as a predictor of response to endocrine therapy. We report on analyses of the relative importance of ER and PR for predicting prognosis using robust multilayer perceptron artificial neural networks. Receptor determinations use immunohistochemical (IHC) methods or radioactive ligand binding assays (LBA). In view of the heterogeneity of intratumoral receptor distribution, we examined the relative merits of the IHC and LBA methods. Our analyses reveal a more significant correlation of IHCdetermined PR than ER with both nodal status and 5-year disease-free survival (DFS). In LBA, PR displayed higher correlation with survival and ER with nodal status. There was concordance of correlation of PR with DFS by both IHC and LBA. This study suggests a clear distinction between PR and ER, with PR displaying greater correlation than ER with disease progression and prognosis, and emphasizes the marked superiority of the IHC method over LBA. These findings may be valuable in the management of patients with breast cancer.

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Disciplines

Computer Sciences

Keywords

Progesterone—Receptors; Estrogen—Receptors; Breast—Cancer; Neural networks (Computer science)

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