The influence of nanostructured materials on biointerfacial interactions
College
College of Science
Department/Unit
Physics
Document Type
Article
Source Title
Advanced Drug Delivery Reviews
Volume
64
Issue
15
First Page
1820
Last Page
1839
Publication Date
12-1-2012
Abstract
Control over biointerfacial interactions in vitro and in vivo is the key to many biomedical applications: from cell culture and diagnostic tools to drug delivery, biomaterials and regenerative medicine. The increasing use of nanostructured materials is placing a greater demand on improving our understanding of how these new materials influence biointerfacial interactions, including protein adsorption and subsequent cellular responses. A range of nanoscale material properties influence these interactions, and material toxicity. The ability to manipulate both material nanochemistry and nanotopography remains challenging in its own right, however, a more in-depth knowledge of the subsequent biological responses to these new materials must occur simultaneously if they are ever to be affective in the clinic. We highlight some of the key technologies used for fabrication of nanostructured materials, examine how nanostructured materials influence the behavior of proteins and cells at surfaces and provide details of important analytical techniques used in this context. © 2012 Elsevier B.V.
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Digitial Object Identifier (DOI)
10.1016/j.addr.2012.06.001
Recommended Citation
Koegler, K., Clayton, A., Thissen, H., Santos, G. C., & Kingshott, P. (2012). The influence of nanostructured materials on biointerfacial interactions. Advanced Drug Delivery Reviews, 64 (15), 1820-1839. https://doi.org/10.1016/j.addr.2012.06.001
Disciplines
Physics
Keywords
Nanoparticles; Nanostructured materials; Cell adhesion; Proteins—Absorption and adsorption; Proteins—Conformation
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