Structural properties of an S-system model of mycobacterium tuberculosis gene regulation

College

College of Science

Department/Unit

Mathematics and Statistics Department

Document Type

Article

Source Title

Philippine Journal of Science

Volume

149

Issue

3

First Page

539

Last Page

555

Publication Date

1-1-2020

Abstract

Magombedze and Mulder (2013) studied the gene regulatory system of Mycobacterium tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the form of S-system, is represented by an embedded chemical reaction network (CRN), defined by a species subset and a reaction subset induced by the set of digraph vertices of the subsystem. For the embedded networks of S-system, we showed interesting structural properties and proved that all S-system CRNs (with at least two species) are discordant. Analyzing the subsystems as subnetworks, where arcs between vertices belonging to different subsystems are retained, we formed a digraph homomorphism from the corresponding subnetworks to the embedded networks. Lastly, we explored the modularity concept of CRN in the context of the digraph. © 2020, Department of Science and Technology. All rights reserved.

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Disciplines

Mathematics | Medicine and Health Sciences

Keywords

Mycobacterium tuberculosis; Gene regulatory networks; Chemical reactions

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