College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
Current Research in Environmental and Applied Mycology
Volume
8
Issue
6
First Page
564
Last Page
571
Publication Date
1-1-2018
Abstract
The present study examined the susceptibility profile of Candida albicans biofilm on latex silicone surfaces to antifungal azoles. Biofilms formed by C. albicans on latex silicone surfaces behaved in accordance with a second-order rate kinetic model. Nonadherent nonbiofilm C. albicans cells were initially susceptible to posaconazole, fluconazole, miconazole, and voriconazole. Biofilms formed by C. albicans on latex silicone surfaces remained susceptible to fluconazole, miconazole, and voriconazole, although a significant reduction in the zone of inhibition diameter was noted at 48-hour to 72-hour biofilm formation. The susceptibility kinetic profile of the fungal biofilm with posaconazole and voriconazole can be described using the zero-order rate kinetic model. Information obtained on these model biofilms with emphasis on susceptibility kinetic profile can possibly explain resistance of antifungal drugs and subsequent development of novel therapies for biofilm-based diseases. © 2018 Beijing Academy of Agriculture and Forestry Sciences, Institute of Plant and Environment Protection.
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Digitial Object Identifier (DOI)
10.5943/cream/8/6/1
Recommended Citation
Sumalapao, D. P., Rippey, C., Atienza, H. P., Cabrera, E. C., Flores, M. C., Amalin, D. M., Altura, M. T., & Gloriani, N. G. (2018). Susceptibility kinetic profile of Candida albicans biofilm on latex silicone surfaces with antifungal azoles. Current Research in Environmental and Applied Mycology, 8 (6), 564-571. https://doi.org/10.5943/cream/8/6/1
Disciplines
Biology
Keywords
Candida albicans; Biofilms; Miconazole; Antifungal agents
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