College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

Current Research in Environmental and Applied Mycology

Volume

8

Issue

6

First Page

564

Last Page

571

Publication Date

1-1-2018

Abstract

The present study examined the susceptibility profile of Candida albicans biofilm on latex silicone surfaces to antifungal azoles. Biofilms formed by C. albicans on latex silicone surfaces behaved in accordance with a second-order rate kinetic model. Nonadherent nonbiofilm C. albicans cells were initially susceptible to posaconazole, fluconazole, miconazole, and voriconazole. Biofilms formed by C. albicans on latex silicone surfaces remained susceptible to fluconazole, miconazole, and voriconazole, although a significant reduction in the zone of inhibition diameter was noted at 48-hour to 72-hour biofilm formation. The susceptibility kinetic profile of the fungal biofilm with posaconazole and voriconazole can be described using the zero-order rate kinetic model. Information obtained on these model biofilms with emphasis on susceptibility kinetic profile can possibly explain resistance of antifungal drugs and subsequent development of novel therapies for biofilm-based diseases. © 2018 Beijing Academy of Agriculture and Forestry Sciences, Institute of Plant and Environment Protection.

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Digitial Object Identifier (DOI)

10.5943/cream/8/6/1

Disciplines

Biology

Keywords

Candida albicans; Biofilms; Miconazole; Antifungal agents

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