Cytotoxic and antimicrobial compounds from Cinnamomum cebuense Kosterm. (Lauraceae)
College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
Pharmaceutical Chemistry Journal
Volume
48
Issue
9
First Page
598
Last Page
602
Publication Date
12-1-2014
Abstract
The dichloromethane extract of Cinnamomum cebuense afforded α-terpineol (1), 4-allyl-2-methoxyphenol or eugenol (2), humulene (3), 4-hydroxy-3-methoxycinnamaldehyde (4) and a monoterpene (5) which were evaluated for cytotoxicity against colon carcinoma (HCT 116). Compound 4 showed moderate cytotoxicity against this cell line with an IC50 value of 18.8004 μg/mL, while 3 and 5 exhibited slight cytotoxicity. Compounds 3 – 5 were further tested for cytotoxicity against non-small cell lung adenocarcinoma (A549) and non-cancer Chinese hamster ovary cells (AA8). Sesquiterpene 3 exhibited moderate cytotoxicity against A549 with an IC50 value of 23.1964 μg/mL, 4 indicated slight cytotoxicity, while 5 was non-toxic against this cell line. Compound 4 showed moderate cytotoxicity against AA8 with an IC50 value of 20.4837 μg/mL, while 3 and 5 exhibited slight cytotoxicity. Compounds 1, 2 and 3 were active against bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis and fungi Candida albicans and Trichophyton mentagrophytes, but were found inactive against Aspergillus niger. Sesquiterpene 3 was the most active against E. coli, P. aeruginosa, S. aureus, C. albicans and T. mentagrophytes, while 1 exhibited the highest activity against B. subtilis, even surpassing the activity of the standard antibiotic chloramphenicol. © 2014, Springer Science+Business Media New York.
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Digitial Object Identifier (DOI)
10.1007/s11094-014-1157-9
Recommended Citation
Espineli, D. L., Agoo, E. G., del Fierro, R. S., Shen, C., & Ragasa, C. Y. (2014). Cytotoxic and antimicrobial compounds from Cinnamomum cebuense Kosterm. (Lauraceae). Pharmaceutical Chemistry Journal, 48 (9), 598-602. https://doi.org/10.1007/s11094-014-1157-9
Disciplines
Biology
Keywords
Cinnamomum--Analysis; Cinnamomum—Toxicity testing; Microbial sensitivity tests
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