Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

Authors

Consolacion Y. Ragasa, De La Salle University Science and Technology Complex
Vincent Antonio S. Ng, De La Salle University, Manila
Mariquit M. De Los Reyes, De La Salle University Science and Technology Complex
Emelina H. Mandia, De La Salle University, Manila
Glenn G. Oyong, De La Salle University, Manila
Chien Chang Shen, National Research Institute of Chinese Medicine Taiwan

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Der Pharma Chemica

Volume

6

Issue

5

First Page

182

Last Page

187

Publication Date

1-1-2014

Abstract

The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract afforded squalene (1), β-sitosterol (2), polyprenols (3) and triglyceride (4). The structures of 1-4 were identified by comparison of their 1H NMR data with those reported in the literature. These compounds are known cytotoxic and anticancer compounds.

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Recommended Citation

Ragasa, C. Y., Ng, V. S., De Los Reyes, M. M., Mandia, E. H., Oyong, G. G., & Shen, C. (2014). Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.. Der Pharma Chemica, 6 (5), 182-187. Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/1778

Disciplines

Chemistry

Keywords

Meliaceae--Analysis; Meliaceae—Toxicity testing; Foliar diagnosis

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