Analgesic triterpenes from Ardisia cf. elliptica (subgenus: Tinus) (Myrsinaceae)
College
College of Science
Department/Unit
Chemistry
Document Type
Article
Source Title
Der Pharma Chemica
Volume
6
Issue
4
First Page
153
Last Page
161
Publication Date
1-1-2014
Abstract
The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and α-amyrin (1c). Their structures were identified by NMR spectroscopy. The mixtures of triterpenes (1a-1c) at ratios of 2:2:1 and 1:1:1 were tested for their analgesic property using the hot plate, tail flick and acetic acid-induced writhing assays. Results from the hot plate assay indicate that 5, 10, and 50 mg kg-1 body weight (BW) of 1a-1c (2:2:1) had analgesic activity comparable to the positive drug control (Diclofenac) at 75 min. Both ratios of 1a-1c were found not effective in the tail flick assay. The mixture (2:2:1) was found most effective in the acetic acid writhing assay. Reduced analgesic activity however was observed in the other mixture (1:1:1).
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Recommended Citation
Raga, D. D., Diezmos, M. S., Orantia, A. C., Lo, M. A., Evangelista, J. P., Kim, S., Shen, C., & Ragasa, C. Y. (2014). Analgesic triterpenes from Ardisia cf. elliptica (subgenus: Tinus) (Myrsinaceae). Der Pharma Chemica, 6 (4), 153-161. Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/1649
Disciplines
Chemistry
Keywords
Myrsinaceae--Analysis; Phanerogams; Analgesics
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