A bioactive diterpene from Smallanthus sonchifolius
College
College of Science
Department/Unit
Chemistry
Document Type
Article
Source Title
Natural Product Communications
Volume
3
Issue
10
First Page
1663
Last Page
1666
Publication Date
1-1-2008
Abstract
The dichloromethane extract of the air-dried leaves and freeze-dried tubers of Smallanthus sonchifolius afforded ent-kaurenoic acid (1). The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy and was found to exhibit significant analgesic and anti-inflammatory activities. Ent-kaurenoic acid (1), dissolved in dimethylsulfoxide, also displayed potential anti-diabetes and anti-toxicity activity. In addition, 1 showed low antimicrobial activities against E. coli, P. aeruginosa, S. aureus, C. albicans and T. mentagrophytes, but was found to be inactive against B. subtilis and A. niger.
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Digitial Object Identifier (DOI)
10.1177/1934578x0800301016
Recommended Citation
Ragasa, C. Y., Alimboyoguen, A. B., Urban, S., & Raga, D. D. (2008). A bioactive diterpene from Smallanthus sonchifolius. Natural Product Communications, 3 (10), 1663-1666. https://doi.org/10.1177/1934578x0800301016
Disciplines
Chemistry
Keywords
Yacon; Diterpenes; Analgesics; Anti-inflammatory agents; Compositae
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