Bioactive triterpenes from Diospyros blancoi

Authors

Consolacion Y. Ragasa, De La Salle University, Manila
Marc Rhyan Anthony Puno, De La Salle University, Manila
Josephine Marie Angeline P. Sengson, De La Salle University, Manila
Chien Chang Shen, National Research Institute of Chinese Medicine Taiwan
John A. Rideout, CQUniversity Australia
Dennis D. Raga, Center for Natural Sciences and Ecological Research

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Natural Product Research

Volume

23

Issue

13

First Page

1252

Last Page

1258

Publication Date

9-1-2009

Abstract

The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of -amyrin palmitate, -amyrin palmitoleate, -amyrin palmitate and -amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.

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Digitial Object Identifier (DOI)

10.1080/14786410902951054

Recommended Citation

Ragasa, C. Y., Puno, M., Sengson, J. P., Shen, C., Rideout, J. A., & Raga, D. D. (2009). Bioactive triterpenes from Diospyros blancoi. Natural Product Research, 23 (13), 1252-1258. https://doi.org/10.1080/14786410902951054

Disciplines

Chemistry

Keywords

Diospyros--Analysis; Amyrin; Analgesics; Anti-inflammatory agents; Anti-infective agents; Ebenaceae

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