A facile and highly efficient one-step N-alkylation of thiazolidine-2,4-dione

Authors

Virgilio D. Ebajo Jr., de la salle

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Arkivoc

Volume

8

Publication Date

2024

Abstract

N-Alkylation of thiazolidine-2,4-diones (TZDs) commonly employs the conversion of TZD to a salt with a strong base, which is then reacted with alkyl halides or alkyl tosylates. This two-step approach suffers from low overall yields, long reaction times, use of high temperatures, and generation of large amounts of waste. Herein, we describe a one-step N-alkylation of TZD with alkyl bromides at room temperature using a small amount of triethylamine as base and solvent. The reaction is fast and convenient, and it exclusively affords N-alkylated products in high yields.

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Recommended Citation

Ebajo, V. D. (2024). A facile and highly efficient one-step N-alkylation of thiazolidine-2,4-dione. Arkivoc, 8 Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/13809

Disciplines

Chemistry

Keywords

Thiazoles; Alkylation

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