Antibiograms of nosocomial staphylococcal isolates from Philippine General Hospital in the first quarter of 2001

College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

Acta Manilana

Volume

51

First Page

21

Last Page

29

Publication Date

2003

Abstract

The antibiograms of sixty-eight (68) staphylococcal isolates obtained from Philippine General Hospital (PGH) from January to March 2001 were determined employing the NCCLS recommended disc agar diffusion technique and minimum inhibitory concentration (MIC) determination of selected antimicrobials through E-test strips. Results revealed that the isolates were mostly resistant to penicillins, oxacillin and trimethoprim. About 7 percent and 67 percent of coagulase positive and coagulase negative isolates were multiple drug resistant strains. They were resistant to at least four antimicrobials tested. Resistance to wide chemical classes of drugs was demonstrated by these isolates. Levels of resistance were shown to be higher among coagulase negative than coagulase positive strains. All isolates, however, were susceptible to nitrofurantoin and vancomycin. Nonetheless, isolates with reduced susceptibility to vancomycin with MIC of 4-6 ug/mL were noted. Inducible resistance to clindamycin by erythromycin was also checked among erythromycin resistant isolates using the double-disc diffusion technique. None of the isolates tested showed lincosamide inducible resistance by the macrolide.

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Disciplines

Microbiology

Keywords

Anti-infective agents; Staphylococcus; Staphylococcal infections

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