Evaluation of the potential anti-viral activity of microRNAs in rainbow trout

College

College of Science

Document Type

Archival Material/Manuscript

Publication Date

6-2013

Abstract

Background: Microribonucleic acids (miRNAs) are small (18-22 nucleotides) endogenous RNAs that potently mediate post-transcriptional silencing of a wide range of genes. They are emerging as critical regulators of cellular processes and some miRNAs have been demonstrated to possess direct antiviral effects. We have previously observed and validated that the fish-specific miRNAs, miR-462 and miR- 731, were among the most highly expressed miRNAs in rainbow trout liver following Viral hemorrhagic septicemia virus (VHSV) infection. These miRNAs were also upregulated in the liver and muscle (vaccination site) of fish vaccinated with a DNA vaccine encoding the glycoprotein gene of VHSV. Recent studies further suggest that the expression of these miRNAs is induced by type I interferons (IFN). Here, we analyzed if miR-462 and miR-731 have antiviral effect contributing to the potent antiviral activity of type I IFNs.

html

Disciplines

Biology | Biotechnology

Keywords

MicroRNA; Antiviral agents; Host-parasite relationships; Osteichthyes—Virus diseases

Upload File

wf_no

This document is currently not available here.

Share

COinS