The role of decorin in cardiovascular diseases: More than just a decoration

College

College of Science

Document Type

Article

Source Title

Free Radical Research

Volume

52

Issue

11-12

First Page

1210

Last Page

1219

Publication Date

2018

Abstract

Decorin (DCN) is a proteoglycan constituent of the extracellular matrix (ECM) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. By attaching to receptors in the cell surface or to several ECM molecules, it regulates plenty of cellular functions, consequently influencing cell differentiation, proliferation, and apoptosis. These processes are dependent on cell types, biological contexts, and interfere with pathological processes such as cardiovascular diseases. In this review, we briefly discuss the potential of DCN targeting in addressing cardiovascular dis- eases (CVD). We dive into its interactome and discuss how its interaction with the proteins can affect disease progression, and how DCN can be a possible target for CVD therapeutics.

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Digitial Object Identifier (DOI)

https://doi.org/10.1080/10715762.2018.1516285

Disciplines

Physiology

Keywords

Extracellular matrix proteins; Heart failure; Mitochondria

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