Exercise-induced mitochondrial adaptations in addressing heart failure

College

College of Science

Document Type

Book Chapter

Source Title

Exercise for Cardiovascular Disease Prevention and Treatment

First Page

323

Last Page

332

Publication Date

2017

Abstract

Mitochondria are complex organelles essential for the production of energy. These dynamic, complex organelles found in every cell and tissues of the body have been well-studied in various physiological models, stressing that mitochondrial dysfunction is characteristic of pathological states, especially in cardio-vascular diseases and heart failure. Since heart failure progresses due to energy deficits brought about by altered mitochondrial bioenergetics and functioning, novel ways of ameliorating mitochondrial dysfunction are being studied. Interestingly, various exercise modalities can serve as stimuli which can regulate the mitochondria in different ways, such as in the increase of mitochondrial mass and copy number, in the structural fusion and fission processes, and the removal of impaired mitochondria. Considering that there are numerous kinds and protocols for exercise, there are a number of ways exercise can affect the mitochondria as well. Nonetheless these processes affect each other to an extent, highlighting the pivotal role exercise plays in improving or enhancing the state of mitochondria during disease. This chapter will focus on how exercise of different can regulate mitochondrial processes, which could be used as therapeutic strategies in addressing heart failure.

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Digitial Object Identifier (DOI)

DOI 10.1007/978-981-10-4304-8_17

Disciplines

Cardiovascular Diseases

Series Title

Advances in experimental medicine and biology ; 1000

Keywords

Mitochondria; Heart failure; MicroRNA

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