Rescue of heart failure by mitochondrial recovery

College

College of Science

Document Type

Article

Source Title

International Neurourology Journal

Volume

20

First Page

5

Last Page

12

Publication Date

2016

Abstract

Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an important role in the progression of HF, and numerous studies have highlighted mitochondrial components that contribute to HF. This review presents an overview of the role of mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial permeability transition pore in HF, discusses ongoing studies that attempt to address the disease through mitochondrial targeting, and provides an insight on how these studies can affect future research on HF treatment.

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Digitial Object Identifier (DOI)

https://doi.org/10.5213/inj.1632570.285, 2016

Disciplines

Cardiovascular Diseases | Systems and Integrative Physiology

Keywords

Mitochondria; Heart failure

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