Influence of starvation on heart contractility and corticosterone level in rats

College

College of Science

Document Type

Article

Source Title

Pflügers Archiv-European Journal of Physiology

Volume

467

First Page

2351

Last Page

2360

Publication Date

2015

Abstract

The physiological changes, including cardiac modification, that occur during starvation are not yet completely understood. The purpose of this study is to examine the effects of a 2-week starvation period on heart contractility, muscle mass, and irisin and corticosterone levels in rats. Rats in the starved group showed a significant reduction in the body, heart, kidney, and muscle weight (n=23, p0.05). In the starvation group, the impairment of cardiac output was dependent on the reduction in stroke volume and heart rate. Starvation induced a severe reduction in ejection fraction and fractional shortening when compared with the body-weight-matched control group (p

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Digitial Object Identifier (DOI)

https://doi.org/10.1007/s00424-015-1701-9

Disciplines

Cardiovascular System | Physiology

Keywords

Starvation—Physiological effect; Heart—Contraction

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