HER2/neu expression in patients with primary uterine endometrial carcinomas in Batangas Medical Center, Philippines

College

College of Science

Document Type

Article

Source Title

Virchows Archiv

Volume

479

Issue

Supplement 1

Publication Date

8-2021

Abstract

Background & objectives: Uterine cancer is the eighth leading cancer among women with an estimated age-standardized Philippine incidence rate of5.6 per 100,000. To aid in the prognostication and management of endometrial cancers, expression ofHER2/neu in Filipinos with endome­trial cancer was determined.

Methods: Sixty-seven cases out of all 71 resection specimens with endo­metrial cancer, from 2017 to 2019, were included in the study. Exclusion of the 4 cases was due to unavailability of paraffin blocks. Histological section was taken for immunohistochernical staining with HER2/neu. Previously proposed HER2 testing algorithm for endometrial carcinoma (EC), based on the modified 2007 ASCO/CAP breast criteria, was used.

Results: Eighty-six percent of the patients were 45 years and older. Ninety-five percent were of endometrioid histologic type, 2 (2.98%) cases were serous, and I (1.49%) case was mixed Mullerian tumour. Lymph node metastasis was present in 6.0% of cases. Most of the cases (65.67%) belonged to FIGO Stage I. HER2/neu was positive (3+) in 27.3% (3/11) of endometrioid grade 3, 14.3% (3/21) of endometrioid grade 2, and 6.1 % (2/33) of endometrioid grade 1. Among the two cases with serous EC, one was positive while the other was negative. The single case of mixed Mullerian tumour was positive for HER2/neu. HER2/neu was either negative or equivocal in cases with node metastasis.

Conclusion: Although most of the HER/neu positive cases in this study were seen in tumours with higher histologic grade, Fisher Freeman Halton test showed no sufficient evidence to say that age, lymph node involvement, FIGO grading and cancer staging were associated with HER2/neu expression. Since literatures show HER2/neu had significant association on prognosis, overall survival, and has potential for targeted therapy and/or as adjunct to chemotherapy, a larger, multicentre study is warranted.

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Disciplines

Medicine and Health Sciences | Oncology

Note

Abstract only

Keywords

Uterus—Cancer—Philippines

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