Chemical constituents of macaranga grandifolia

Date of Publication

2020

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Advisor

Consolacion Y. Ragasa

Defense Panel Chair

Jaime Raul O. Janairo

Defense Panel Member

Glenn V. Alea
Alicia M. Aguinaldo

Abstract/Summary

Macaranga grandifolia also known as “takip-asin” or “Binuñgang-malapad” in tagalong, is a small deciduous tree found in secondary forest at low altitudes in Luzon and Mindoro. The leaves are used as fodder, to wrap food and its ash is eaten for enlarged bellies. The resin is utilized as a glue for musical instruments and as astringent gargle for mouth ulcers. Chemical investigation of the dichloromethane extracts of Macaranga grandifolia has led to the isolation of vedelianin (1-MGrL01), squalene (2-MGrL03), -carotene (3-MGrL04), and polyprenol (4-MGrL05) from the leaves; a mixture of β-sitosterol and stigmasterol (5-MGrB2); and monoacylglycerols (6-MGrF08) and saturated fatty acids (7-MGrF13) from the fruit. The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy, while those of 2-7 were identified comparison of their NMR data with literature data. This is the first report on the isolation of these compounds from M. grandifolia.

Abstract Format

html

Language

English

Format

Electronic

Physical Description

xiii, 159 leaves

Keywords

Euphorbiaceae--Analysis

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Embargo Period

4-21-2023

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