Date of Publication

2022

Document Type

Dissertation/Thesis

Degree Name

Master of Science in Biology

Subject Categories

Biology

College

College of Science

Department/Unit

Biology

Thesis Advisor

Gliceria B. Ramos

Defense Panel Chair

Mariquit M. de los Reyes

Defense Panel Member

Peniel Jean A. Gildo
Tosha Mae S. Manalastas

Abstract/Summary

The development of tissue replacement, especially for the kidneys, remains a supreme discipline owing to its anatomic and physiological complexity. Each region of the kidney extracellular matrix (ECM) possesses unique structural, biochemical, and functional characteristics. This regional specificity of the kidney ECM can potentially affect the properties of the hydrogel produced from each region. In this study, hydrogels derived from the renal cortex and renal medulla of the decellularized porcine kidney were developed, characterized, and compared. Hydrogel production involved a series of procedures such as decellularization, solubilization, neutralization, and gelation. The hydrogels were evaluated in terms of surface topography, swelling capacity, and spectral analysis. Results showed that the hydrogels derived from the renal cortex and renal medulla show similar physicochemical properties such as an interconnected porous hydrogel network, swelling behavior and ratio, and chemical structure. The preliminary results of this work can hopefully aid in the pursuit of tested, biocompatible, and ethical solutions to treat diseased and damaged kidneys.

Abstract Format

html

Language

English

Format

Electronic

Physical Description

185 leaves

Keywords

Kidney cortex; Kidneys; Colloids

Upload Full Text

wf_yes

Embargo Period

9-7-2024

Available for download on Saturday, September 07, 2024

Share

COinS