Date of Publication

4-10-2025

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Manufacturing Engineering and Management w/ Spec in Biomedical Engineering

Subject Categories

Biomedical Engineering and Bioengineering

College

Gokongwei College of Engineering

Department/Unit

Manufacturing Engineering and Management

Thesis Advisor

Joseph Rey Sta. Agueda

Defense Panel Chair

Richard Josiah Tan Ai

Defense Panel Member

Catherine Manuela L. Ramos
Homer Co

Abstract (English)

Microneedle (MN) patches represent a novel approach to transdermal drug delivery, offering a minimally invasive method for injecting different medications. Despite their increased adoption, there is currently no established data to determine an efficient and reproducible microneedle design based on shape, needle spacing, and MN length for dissolvable microneedle patch for wound healing applications. This study aims to design a dissolvable microneedle patch for delivering wound-healing medications through the development of a custom 3D-printed micromold. Through a meticulous design process, the researchers seek to examine the combination of microneedles with a set of fixed parameters that is dissolvable, micromolded, and of PVA/PVP composition, with a 3:1 aspect ratio. Additionally, the researchers will explore a range of independent variables, including the microneedle shape, whether bullet, pyramidal, or conical; the component concentration within the matrix; and the depth of penetration targeted within 300-500 μm. This study will employ computer-aided design (CAD) software for the modeling phase and to ensure the structural integrity and mechanical stability of the microneedle designs, Finite Element Analysis (FEA) was conducted using ANSYS. This evaluates the mechanical parameters such as total deformation, stress distribution, insertion pressure, and the factor of safety under applied force then followed by the preparation of the polymer-medicine material to which the prototyped array will then undergo composition analysis using Fourier Transform Infrared Spectroscopy (FTIR), swell tests, mechanical tests on UniVert, and insertion efficiency tests using on porcine skin.

Keywords — manufacturing engineering, microneedles, 3D printing, micro mold, ANSYS

Abstract Format

html

Abstract (Filipino)

None

Abstract Format

html

Language

English

Format

Electronic

Keywords

Polyvinyl alcohol; Povidone

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Embargo Period

4-9-2026

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