Plant extract-mediated synthesis and characterization of manganese (II, III) oxide nanoparticles from watermelon (Citrullus lanatus) rinds extract for potential theranostic applications

Author

Gelo P. Zaragosa, De La Salle University, ManilaFollow
Carlo Nonato D. Ilem, De La Salle University, ManilaFollow

Date of Publication

4-2023

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Advisor

Joel Garcia

Defense Panel Member

Lourdes P. Guidote
Searle Aichelle Duay

Abstract/Summary

Green synthesis of Mn₃O₄ nanoparticles for theranostic applications was performed utilizing the plant extract of watermelon (Citrullus lanatus) rinds as a reducing and stabilizing agent. The optical, chemical, structural, and morphological properties of the synthesized Mn₃O₄ nanoparticles were characterized. UV-Visible absorption of the nanoparticles at 196 nm is associated with the surface plasmon resonance of Mn₃O₄ nanoparticles. FTIR spectra presented the key chemical functional groups associated with the Mn-O vibrations and phytoconstituents of the C. lanatus rinds extract. XRD analysis revealed the single-phase hausmannite crystalline structure of the Mn₃O₄ nanoparticles with an average crystallite size of 35.2 nm. SEM and TEM images of the synthesized Mn₃O₄ nanoparticles showed a morphology of quasi-spherical shapes and a core size of 52.90 ± 8.19 nm and 35.89 ± 0.83 nm respectively. EDS analysis confirmed that the synthesized nanoparticles are mainly composed of Mn, O, and C. The nanoparticles were investigated through DLS and were found to be stable with time and physiological pH conditions. Furthermore, the synthesized Mn₃O₄ nanoparticles were tested for their antioxidant and relaxivity capabilities as a theranostic agent. The radical scavenging activity through the DPPH assay revealed that the nanoparticles possessed profound antioxidant therapeutic capabilities obtaining an IC₅₀ value of 20.62 ± 0.69 ppm. Relaxivity measurements through NMR revealed the T1 and T2 relaxivity values of the Mn3O4 nanoparticles, which were found to be 5.34 ± 0.11 mM^-1s-¹ and 63.47 ± 0.60 mM^-1s^-1 respectively, that demonstrates its capability as a contrast agent for diagnostic imaging. Overall, the results suggest that the green synthesized Mn₃O₄ nanoparticles have the potential to be a theranostic agent for MRI applications.

Abstract Format

html

Language

English

Format

Electronic

Physical Description

147 leaves

Keywords

Manganese oxides; Watermelons

Recommended Citation

Zaragosa, G. P., & Ilem, C. D. (2023). Plant extract-mediated synthesis and characterization of manganese (II, III) oxide nanoparticles from watermelon (Citrullus lanatus) rinds extract for potential theranostic applications. Retrieved from https://animorepository.dlsu.edu.ph/etdb_chem/25

Upload Full Text

wf_yes

Embargo Period

6-15-2025